Mesalamine
Mesalamine Brand names, Mesalamine Analogs
Mesalamine Brand Names Mixture
- No information avaliable
Mesalamine Chemical_Formula
C7H7NO3
Mesalamine RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Mesalamine fda sheet
Mesalamine msds (material safety sheet)
Mesalamine Synthesis Reference
No information avaliable
Mesalamine Molecular Weight
153.135 g/mol
Mesalamine Melting Point
283 oC
Mesalamine H2O Solubility
0.84 g/L at 20°C
Mesalamine State
Solid
Mesalamine LogP
1.012
Mesalamine Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Mesalamine Indication
For the treatment of active ulcerative proctitis.
Mesalamine Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Mesalamine Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Mesalamine side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Mesalamine Patient Information
Mesalamine Organisms Affected
Humans and other mammals
