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Maolate Brand names, Maolate Analogs

Maolate Brand Names Mixture

  • No information avaliable

Maolate Chemical_Formula

C52H98N16O13

Maolate RX_link

No information avaliable

Maolate fda sheet

Maolate msds (material safety sheet)

Maolate MSDS

Maolate Synthesis Reference

No information avaliable

Maolate Molecular Weight

2797.3193 g/mol

Maolate Melting Point

200 - 220 oC

Maolate H2O Solubility

5.64E+005 mg/L

Maolate State

Solid

Maolate LogP

-4.648

Maolate Dosage Forms

Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)

Maolate Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

Maolate Pharmacology

Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

Maolate Absorption

Very poor absorption from gastrointestinal tract.

Maolate side effects and Toxicity

Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

Maolate Patient Information

No information avaliable

Maolate Organisms Affected

Gram-negative bacilli