• Corticosteroid
• Glucocorticoids
• Anti-inflammatory, steroidal
• Immunosuppressant
• ATC:A07EA04
• ATC:C05AA05
• ATC:D07AC01

• Hydrocortamate Hydrochloride
• Magnacort
• Ulcort

C₂₇H₄₁NO₆

No information avaliable

No information avaliable

475.618 g/mol

No information avaliable

No information avaliable

Solid

2.953

Ointment; Cream

Used topically as an antiinflammatory in the treatment of steroid-responsive dermatoses

Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

No information avaliable

Side effects include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria.

http://www.drugs.com/MMX/Homatropine_Methylbromide.html

Humans and other mammals