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Lovasterol
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Lovasterol Brand names, Lovasterol Analogs

Lovasterol Brand Names Mixture

  • No information avaliable

Lovasterol Chemical_Formula

C24H36O5

Lovasterol RX_link

http://www.rxlist.com/cgi/generic3/altocor.htm

Lovasterol fda sheet

Lovasterol FDA

Lovasterol msds (material safety sheet)

Lovasterol Synthesis Reference

R. L. Monaghan et al., U.S. Pat. 4,231,938 (1980)

Lovasterol Molecular Weight

404.54 g/mol

Lovasterol Melting Point

174.5 oC

Lovasterol H2O Solubility

0.0004 mg/mL

Lovasterol State

Solid

Lovasterol LogP

4

Lovasterol Dosage Forms

Tablet

Lovasterol Indication

For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease

Lovasterol Pharmacology

Lovastatin, an antilipemic agent produced by fermentation of Aspergillus terreus, is the first of a class of lipid-lowering agents known as the HMG-CoA reductase inhibitors. Lovastatin is used to treat hypercholesterolemia, to slow coronary atherosclerosis, and to prevent myocardial infarction and stroke. Lovastatin, like simvastin and unlike pravastatin, is a prodrug, concentrating active drug in the liver during first-pass circulation.

Lovasterol Absorption

30%

Lovasterol side effects and Toxicity

LD50>1000 mg/kg (orally in mice)

Lovasterol Patient Information

PATIENT INFORMATION

Lovastatin is used to lower high cholesterol levels. This medication should
not be taken if you are pregnant, nursing, or have liver disease. Lovastatin
should be taken with the evening meal. This medication may cause increased
sensitivity to sunlight. Use sunscreens and wear protective clothing until
degree of sensitivity is determined. Notify your physician if you develop
blurred vision; skin rash; muscle pain, weakness, or cramps; unexplained fever,
or yellowing of the skin or eyes.

Patients should be advised about substances they should not take concomitantly
with lovastatin and be advised to report promptly unexplained muscle pain,
tenderness, or weakness (see list below and WARNINGS, Myopathy/Rhabdomyolysis ).
Patients should also be advised to inform other physicians prescribing a new
medication that they are taking MEVACOR .

Lovasterol Organisms Affected

Humans and other mammals