Lovastatinum [Latin] en es it fr

Lovastatinum [Latin] Brand names, Lovastatinum [Latin] Analogs

Lovastatinum [Latin] Brand Names Mixture

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Lovastatinum [Latin] Chemical_Formula


Lovastatinum [Latin] RX_link


Lovastatinum [Latin] fda sheet

Lovastatinum_[Latin] FDA

Lovastatinum [Latin] msds (material safety sheet)

Lovastatinum [Latin] Synthesis Reference

R. L. Monaghan et al., U.S. Pat. 4,231,938 (1980)

Lovastatinum [Latin] Molecular Weight

404.54 g/mol

Lovastatinum [Latin] Melting Point

174.5 oC

Lovastatinum [Latin] H2O Solubility

0.0004 mg/mL

Lovastatinum [Latin] State


Lovastatinum [Latin] LogP


Lovastatinum [Latin] Dosage Forms


Lovastatinum [Latin] Indication

For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease

Lovastatinum [Latin] Pharmacology

Lovastatin, an antilipemic agent produced by fermentation of Aspergillus terreus, is the first of a class of lipid-lowering agents known as the HMG-CoA reductase inhibitors. Lovastatin is used to treat hypercholesterolemia, to slow coronary atherosclerosis, and to prevent myocardial infarction and stroke. Lovastatin, like simvastin and unlike pravastatin, is a prodrug, concentrating active drug in the liver during first-pass circulation.

Lovastatinum [Latin] Absorption


Lovastatinum [Latin] side effects and Toxicity

LD50>1000 mg/kg (orally in mice)

Lovastatinum [Latin] Patient Information


Lovastatin is used to lower high cholesterol levels. This medication should
not be taken if you are pregnant, nursing, or have liver disease. Lovastatin
should be taken with the evening meal. This medication may cause increased
sensitivity to sunlight. Use sunscreens and wear protective clothing until
degree of sensitivity is determined. Notify your physician if you develop
blurred vision; skin rash; muscle pain, weakness, or cramps; unexplained fever,
or yellowing of the skin or eyes.

Patients should be advised about substances they should not take concomitantly
with lovastatin and be advised to report promptly unexplained muscle pain,
tenderness, or weakness (see list below and WARNINGS, Myopathy/Rhabdomyolysis ).
Patients should also be advised to inform other physicians prescribing a new
medication that they are taking MEVACOR .

Lovastatinum [Latin] Organisms Affected

Humans and other mammals