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Lioresal Brand names, Lioresal Analogs

Lioresal Brand Names Mixture

  • No information avaliable

Lioresal Chemical_Formula

C10H12ClNO2

Lioresal RX_link

http://www.rxlist.com/cgi/generic/baclofen.htm

Lioresal fda sheet

Lioresal FDA

Lioresal msds (material safety sheet)

Lioresal Synthesis Reference

Neth. pat. Appl. 6,407,755; H. Keberle et al., U.S. pat. 3,471,548 (1965, 1969 both to Ciba)

Lioresal Molecular Weight

213.661 g/mol

Lioresal Melting Point

206-208 oC

Lioresal H2O Solubility

2090 mg/L

Lioresal State

Solid

Lioresal LogP

1.42

Lioresal Dosage Forms

Tablet; Intrathecal injection

Lioresal Indication

For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity

Lioresal Pharmacology

Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Lioresal Absorption

Rapidly and extensively absorbed

Lioresal side effects and Toxicity

LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)

Lioresal Patient Information

Lioresal Organisms Affected

Humans and other mammals