Leurocristine en es it fr

Leurocristine Brand names, Leurocristine Analogs

Leurocristine Brand Names Mixture

  • No information avaliable

Leurocristine Chemical_Formula

C46H56N4O10

Leurocristine RX_link

http://www.rxlist.com/cgi/generic3/vincristine.htm

Leurocristine fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=35

Leurocristine msds (material safety sheet)

Leurocristine MSDS

Leurocristine Synthesis Reference

No information avaliable

Leurocristine Molecular Weight

824.958 g/mol

Leurocristine Melting Point

220 oC

Leurocristine H2O Solubility

No information avaliable

Leurocristine State

Solid

Leurocristine LogP

4.918

Leurocristine Dosage Forms

Liquid; Solution

Leurocristine Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

Leurocristine Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Leurocristine Absorption

No information avaliable

Leurocristine side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

Leurocristine Patient Information

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm

http://www.drugs.com/cons/Vincristine.html

Leurocristine Organisms Affected

Humans and other mammals