Lamotrigine
Lamotrigine Brand names, Lamotrigine Analogs
Lamotrigine Brand Names Mixture
- No information avaliable
Lamotrigine Chemical_Formula
C9H7Cl2N5
Lamotrigine RX_link
http://www.rxlist.com/cgi/generic/lamotrigine.htm
Lamotrigine fda sheet
Lamotrigine msds (material safety sheet)
Lamotrigine Synthesis Reference
M. G. Baxter et al., Eur. pat. Appl. 21,121 (1981 to Wellcome Foundation); D. A. Sawyer et al., U.S. pat. 4,602,017 (1986)
Lamotrigine Molecular Weight
256.091 g/mol
Lamotrigine Melting Point
216-218 oC (uncorr)
Lamotrigine H2O Solubility
No information avaliable
Lamotrigine State
Solid
Lamotrigine LogP
1.497
Lamotrigine Dosage Forms
Tablet; Chewable
Lamotrigine Indication
For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome; For the maintenance treatment of Bipolar I Disorder
Lamotrigine Pharmacology
Lamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. Lamotrigine is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lamotrigine inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.
Lamotrigine Absorption
98%
Lamotrigine side effects and Toxicity
LD50=250 (mg/kg) (in rat, mice); LD50>640 orally (mg/kg) (in rat, mice) (Sawyer); Decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, rolling eyeballs
Lamotrigine Patient Information
Lamotrigine Organisms Affected
Humans and other mammals
