L-Penicillamine
Category
L-Penicillamine Brand names, L-Penicillamine Analogs
L-Penicillamine Brand Names Mixture
No information avaliable
L-Penicillamine Chemical_Formula
C5H11NO2S
L-Penicillamine RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
L-Penicillamine fda sheet
L-Penicillamine msds (material safety sheet)
L-Penicillamine Synthesis Reference
No information avaliable
L-Penicillamine Molecular Weight
149.212 g/mol
L-Penicillamine Melting Point
198.5 oC
L-Penicillamine H2O Solubility
1.11E+005 mg/L
L-Penicillamine State
Solid
L-Penicillamine LogP
-2.09
L-Penicillamine Dosage Forms
Capsule; Tablet
L-Penicillamine Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
L-Penicillamine Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
L-Penicillamine Absorption
rapidly but incompletely
L-Penicillamine Toxicity
No information avaliable
L-Penicillamine Patient Information
No information avaliable
L-Penicillamine Organisms Affected
Humans and other mammals
