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L-PAM Brand names, L-PAM Analogs

L-PAM Brand Names Mixture

  • No information avaliable

L-PAM Chemical_Formula

C13H18Cl2N2O2

L-PAM RX_link

http://www.rxlist.com/cgi/generic2/melph.htm

L-PAM fda sheet

L-PAM FDA

L-PAM msds (material safety sheet)

L-PAM Synthesis Reference

Sen, A.K., et al.; Indian J.Chem.Sect.B; 22; 9; 939-941(1983)

L-PAM Molecular Weight

305.2 g/mol

L-PAM Melting Point

182.5 oC

L-PAM H2O Solubility

< 0.1 g/100 mL at 22°C

L-PAM State

Solid

L-PAM LogP

-0.432

L-PAM Dosage Forms

Tablet; Solution (for injection)

L-PAM Indication

For the palliative treatment of multiple myeloma and for the palliation of non-resectable epithelial carcinoma of the ovary.

L-PAM Pharmacology

Melphalan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

L-PAM Absorption

Incomplete, variable, 25-89% post oral dose

L-PAM side effects and Toxicity

Vomiting, ulceration of the mouth, diarrhea, and hemorrhage of the gastrointestinal tract; The principal toxic effect is bone marrow suppression. LD50=11.2 mg/kg (orally in rat)

L-PAM Patient Information

PATIENT INFORMATION

Patients should be informed that the major toxicities of ALKERAN are related
to bone marrow suppression, hypersensitivity reactions, gastrointestinal
toxicity, and pulmonary toxicity. The major long-term toxicities are related
to infertility and secondary malignancies. Patients should never be allowed
to take the drug without close medical supervision and should be advised to
consult their physician if they experience skin rash, vasculitis, bleeding,
fever, persistent cough, nausea, vomiting, amenorrhea, weight loss, or unusual
lumps/masses. Women of childbearing potential should be advised to avoid
becoming pregnant.

Laboratory Tests: Periodic complete blood counts with differentials should be
performed during the course of treatment with ALKERAN. At least one determination
should be obtained prior to each treatment course. Patients should be observed
closely for consequences of bone marrow suppression, which include severe infections,
bleeding, and symptomatic anemia.

L-PAM Organisms Affected

Humans and other mammals