Ketotifene_fumarate
Category
Ketotifene_fumarate Brand names, Ketotifene_fumarate Analogs
Ketotifene_fumarate Brand Names Mixture
No information avaliable
Ketotifene_fumarate Chemical_Formula
C11H12N2S
Ketotifene_fumarate RX_link
http://www.rxlist.com/cgi/generic3/levamisole.htm
Ketotifene_fumarate fda sheet
Ketotifene_fumarate msds (material safety sheet)
Ketotifene_fumarate Synthesis Reference
No information avaliable
Ketotifene_fumarate Molecular Weight
204.292 g/mol
Ketotifene_fumarate Melting Point
264-265 oC
Ketotifene_fumarate H2O Solubility
210 mg/mL
Ketotifene_fumarate State
Solid
Ketotifene_fumarate LogP
2.046
Ketotifene_fumarate Dosage Forms
Tablet
Ketotifene_fumarate Indication
For adjuvant treatment in combination with fluorouracil after surgical resection in patients with Dukes' stage C colon cancer. Also used to treat malignant melanoma and head/neck cancer.
Ketotifene_fumarate Pharmacology
Levamisole is a synthetic imidazothiazole derivative that has been widely used in treatment of worm infestations in both humans and animals. As an anthelmintic, it probably works by targeting the nematode nicotinergic acetylcholine receptor. As an immunomodulator, it appears that Levamisole is an immunostimulant which has been shown to increase NK cells and activated T-cells in patients receiving this adjuvantly along with 5FU for Stage III colon cancer.
Ketotifene_fumarate Absorption
Levamisole is rapidly absorbed (2 hours) from the gastrointestinal tract.
Ketotifene_fumarate Toxicity
LD50 = 40 mg/kg (Pigs, subcutaneous); LD50 = 180 mg/kg (rat, oral)
Ketotifene_fumarate Patient Information
http://www.drugs.com/MTM/letrozole.html
Ketotifene_fumarate Organisms Affected
Humans and other mammals
