Kanamycin Base

• Anti-bacterial Agents
• ATC:A07AA08
• ATC:J01GB04
• ATC:S01AA24

• Aminodeoxykanamycin
• Bekanamycin
• KAN
• Kanamycin A
• Kanamycin B
• Kanamycin Base
• Kanamycin Sulfate
• Kantrex
• Kenamycin A
• Klebcil
• Nebramycin Factor 5

• No information avaliable

C₁₈H₃₆N₄O₁₁

http://www.rxlist.com/cgi/generic3/kanamycin.htm

Kanamycin_Base MSDS

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484.499 g/mol

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Solid

-7.936

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For treatment of infections where one or more of the following are the known or suspected pathogens: E. coli, Proteus species (both indole-positive and indole-negative), E. aerogenes, K. pneumoniae, S. marcescens, and Acinetobacter species.

Kanamycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

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LD 50 - ORAL, MOUSE = 17500 MG/KG, LD 50 - ORAL, RAT = >4 GM/KG, LD 50 - ORAL, RABBIT = >3 GM/KG

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Enteric bacteria and other eubacteria