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Instotal Brand names, Instotal Analogs

Instotal Brand Names Mixture

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Instotal Chemical_Formula


Instotal RX_link

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Instotal fda sheet

Instotal msds (material safety sheet)

Instotal Synthesis Reference

G. Gueremy et al., Ger. pat. 2,009,555 corresp to U.S. pat. 3,987,042 (1970, 1976 to Sogeras)

Instotal Molecular Weight

322.468 g/mol

Instotal Melting Point

130.5 oC

Instotal H2O Solubility

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Instotal State


Instotal LogP


Instotal Dosage Forms


Instotal Indication

For the treatment of Hay fever, urticaria (hives) and allergic rhinitis

Instotal Pharmacology

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Mequitazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Instotal Absorption

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Instotal side effects and Toxicity

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Instotal Patient Information

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Instotal Organisms Affected

Humans and other mammals