Imatinib Methansulfonate en es it fr

Imatinib Methansulfonate Brand names, Imatinib Methansulfonate Analogs

Imatinib Methansulfonate Brand Names Mixture

  • No information avaliable

Imatinib Methansulfonate Chemical_Formula

C29H31N7O

Imatinib Methansulfonate RX_link

http://www.rxlist.com/cgi/generic3/gleevec.htm

Imatinib Methansulfonate fda sheet

Imatinib_Methansulfonate FDA

Imatinib Methansulfonate msds (material safety sheet)

Imatinib Methansulfonate Synthesis Reference

No information avaliable

Imatinib Methansulfonate Molecular Weight

493.603 g/mol

Imatinib Methansulfonate Melting Point

226 oC (mesylate salt)

Imatinib Methansulfonate H2O Solubility

Very soluble in water at pH < 5.5 (mesylate salt)

Imatinib Methansulfonate State

Solid

Imatinib Methansulfonate LogP

3.218

Imatinib Methansulfonate Dosage Forms

Capsule; Tablet

Imatinib Methansulfonate Indication

For the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (CML). Also indicated for the treatment of pediatric patients with Ph+ chronic phase CML whose disease has recurred after stem cell transplant or who are resistant to interferon-alpha therapy. Also indicated with unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST).

Imatinib Methansulfonate Pharmacology

Imatinib is an antineoplastic agent used to treat chronic myelogenous leukemia. Imatinib is a 2-phenylaminopyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of Abl with Bcr (breakpoint cluster region), termed Bcr-Abl. As this is now a continuously active tyrosine kinase, Imatinib is used to decrease Bcr-Abl activity.

Imatinib Methansulfonate Absorption

Imatinib is well absorbed with mean absolute bioavailability is 98% with maximum levels achieved within 2-4 hours of dosing

Imatinib Methansulfonate side effects and Toxicity

Side effects include nausea, vomiting, diarrhea, loss of appetite, dry skin, hair loss, swelling (especially in the legs or around the eyes) and muscle cramps

Imatinib Methansulfonate Patient Information

Imatinib Methansulfonate Organisms Affected

Humans and other mammals