Imatinib Mesylate

Imatinib Mesylate Brand names, Imatinib Mesylate Analogs

Imatinib Mesylate Brand Names Mixture

No information avaliable

Imatinib Mesylate Chemical_Formula

C₂₉H₃₁N₇O

Imatinib Mesylate RX_link

http://www.rxlist.com/cgi/generic3/gleevec.htm

Imatinib Mesylate fda sheet

Imatinib_Mesylate FDA

Imatinib Mesylate msds (material safety sheet)

Imatinib Mesylate Synthesis Reference

No information avaliable

Imatinib Mesylate Molecular Weight

493.603 g/mol

Imatinib Mesylate Melting Point

226 ^oC (mesylate salt)

Imatinib Mesylate H₂O Solubility

Very soluble in water at pH < 5.5 (mesylate salt)

Imatinib Mesylate State

Solid

Imatinib Mesylate LogP

3.218

Imatinib Mesylate Dosage Forms

Capsule; Tablet

Imatinib Mesylate Indication

For the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (CML). Also indicated for the treatment of pediatric patients with Ph+ chronic phase CML whose disease has recurred after stem cell transplant or who are resistant to interferon-alpha therapy. Also indicated with unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST).

Imatinib Mesylate Pharmacology

Imatinib is an antineoplastic agent used to treat chronic myelogenous leukemia. Imatinib is a 2-phenylaminopyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of Abl with Bcr (breakpoint cluster region), termed Bcr-Abl. As this is now a continuously active tyrosine kinase, Imatinib is used to decrease Bcr-Abl activity.

Imatinib Mesylate Absorption

Imatinib is well absorbed with mean absolute bioavailability is 98% with maximum levels achieved within 2-4 hours of dosing

Imatinib Mesylate side effects and Toxicity

Side effects include nausea, vomiting, diarrhea, loss of appetite, dry skin, hair loss, swelling (especially in the legs or around the eyes) and muscle cramps

Imatinib Mesylate Patient Information

Imatinib Mesylate Organisms Affected

Humans and other mammals