Ig gamma-1 chain C region en es it fr

Ig gamma-1 chain C region Brand names, Ig gamma-1 chain C region Analogs

Ig gamma-1 chain C region Brand Names Mixture

  • No information avaliable

Ig gamma-1 chain C region Chemical_Formula

C6428H9912N1694O1987S46

Ig gamma-1 chain C region RX_link

http://www.rxlist.com/cgi/generic3/infliximab.htm

Ig gamma-1 chain C region fda sheet

Ig gamma-1 chain C region msds (material safety sheet)

Ig gamma-1 chain C region Synthesis Reference

U.S. patent 6,015,557, Nagahira K, Fukuda Y, Oyama Y, Kurihara T, Nasu T, Kawashima H, Noguchi C, Oikawa S, Nakanishi T. Humanization of a mouse neutralizing monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha).

Ig gamma-1 chain C region Molecular Weight

144190.3

Ig gamma-1 chain C region Melting Point

61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).

Ig gamma-1 chain C region H2O Solubility

No information avaliable

Ig gamma-1 chain C region State

Liquid

Ig gamma-1 chain C region LogP

-0.441

Ig gamma-1 chain C region Dosage Forms

Powder for solution; Solution (IV infusion)

Ig gamma-1 chain C region Indication

For treatment of Crohn's disease, psoriasis, rheumatoid arthitis and ankylosing spondylitis

Ig gamma-1 chain C region Pharmacology

Used in the treatment of auto-immune disorders such as Crohn's disease and rheumatoid arthritis. Infliximab binds to tumor necrosis factor alpha (TNFa) and inhibits binding of TNFa with its receptors. This reduces production of pro-inflammatory cytokines such as interleukins (IL) 1 and 6. This also limits leukocyte migration and expression of adhesion molecules by endothelial cells and leukocytes. Infliximab also limits the activation of neutrophil and eosinophil functional activity, reduces production of tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Infliximab decreases synovitis and joint erosions in collagen-induced arthritis and allows eroded joints to heal.

Ig gamma-1 chain C region Absorption

No information avaliable

Ig gamma-1 chain C region side effects and Toxicity

No information avaliable

Ig gamma-1 chain C region Patient Information

BIOD00004.html

Ig gamma-1 chain C region Organisms Affected

Humans and other mammals