Ifosfamide

Category

Ifosfamide




Useful info

Ifosfamide Brand names, Ifosfamide Analogs

Ifosfamide Brand Names Mixture

  • No information avaliable

    • Ifosfamide Chemical_Formula

    C7H15Cl2N2O2P

    Ifosfamide RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Ifosfamide fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Ifosfamide msds (material safety sheet)

    Ifosfamide MSDS

    Ifosfamide Synthesis Reference

    No information avaliable

    Ifosfamide Molecular Weight

    261.085 g/mol

    Ifosfamide Melting Point

    39-41 oC

    Ifosfamide H2O Solubility

    3780 mg/L

    Ifosfamide State

    Solid

    Ifosfamide LogP

    -0.01

    Ifosfamide Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Ifosfamide Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Ifosfamide Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Ifosfamide Absorption

    No information avaliable

    Ifosfamide Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Ifosfamide Patient Information

    No information avaliable

    Ifosfamide Organisms Affected

    Humans and other mammals