IL-1RN

• Antirheumatic Agents
• Immunomodulatory Agents

• ICIL-1RA
• IL-1RN
• IL-1ra
• IL1 inhibitor
• IRAP
• Interleukin-1 receptor antagonist protein precursor
• Kineret (Amgen Inc)

• No information avaliable

C₇₅₉H₁₁₈₆N₂₀₈O₂₃₂S₁₀

http://www.rxlist.com/cgi/generic/anakinra.htm

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17257.6

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Liquid

-0.412

Solution

For treatment of adult rheumatoid arthritis

Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1.

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BIOD00060.html

Humans and other mammals