Holbamate
Category
Holbamate Brand names, Holbamate Analogs
Holbamate Brand Names Mixture
Holbamate Chemical_Formula
C20H23NS
Holbamate RX_link
No information avaliable
Holbamate fda sheet
Holbamate msds (material safety sheet)
Holbamate Synthesis Reference
No information avaliable
Holbamate Molecular Weight
309.469 g/mol
Holbamate Melting Point
< 25 oC
Holbamate H2O Solubility
Soluble as HCl salt
Holbamate State
Liquid
Holbamate LogP
5.7
Holbamate Dosage Forms
Tablets (oral, 1 mg)
Holbamate Indication
Used for the symptomatic treatment of parkinsonism.
Holbamate Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Holbamate Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Holbamate side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Holbamate Patient Information
Holbamate Organisms Affected
Humans and other mammals
