Hepsera
Hepsera Brand names, Hepsera Analogs
Hepsera Brand Names Mixture
- No information avaliable
Hepsera Chemical_Formula
C20H32N5O8P
Hepsera RX_link
http://www.rxlist.com/cgi/generic3/hepsera.htm
Hepsera fda sheet
Hepsera msds (material safety sheet)
Hepsera Synthesis Reference
No information avaliable
Hepsera Molecular Weight
501.471 g/mol
Hepsera Melting Point
No information avaliable
Hepsera H2O Solubility
19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.
Hepsera State
Solid
Hepsera LogP
3.649
Hepsera Dosage Forms
Tablet (10 mg)
Hepsera Indication
For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Hepsera Pharmacology
Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.
Hepsera Absorption
Approximate oral bioavailability is 59%.
Hepsera side effects and Toxicity
Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.
Hepsera Patient Information
Hepsera Organisms Affected
Hepatitis B virus
