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Hemel Brand names, Hemel Analogs

Hemel Brand Names Mixture

  • No information avaliable

Hemel Chemical_Formula

C9H18N6

Hemel RX_link

http://www.rxlist.com/cgi/generic/altretamine.htm

Hemel fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=104

Hemel msds (material safety sheet)

Hemel Synthesis Reference

No information avaliable

Hemel Molecular Weight

210.28 g/mol

Hemel Melting Point

172-174 oC

Hemel H2O Solubility

91 mg/L

Hemel State

Solid

Hemel LogP

1.566

Hemel Dosage Forms

Capsule

Hemel Indication

For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

Hemel Pharmacology

Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.

Hemel Absorption

No information avaliable

Hemel side effects and Toxicity

No information avaliable

Hemel Patient Information

No information avaliable

Hemel Organisms Affected

Humans and other mammals