HTM
HTM Brand names, HTM Analogs
HTM Brand Names Mixture
- No information avaliable
HTM Chemical_Formula
C9H18N6
HTM RX_link
http://www.rxlist.com/cgi/generic/altretamine.htm
HTM fda sheet
HTM msds (material safety sheet)
HTM Synthesis Reference
No information avaliable
HTM Molecular Weight
210.28 g/mol
HTM Melting Point
172-174 oC
HTM H2O Solubility
91 mg/L
HTM State
Solid
HTM LogP
1.566
HTM Dosage Forms
Capsule
HTM Indication
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
HTM Pharmacology
Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
HTM Absorption
No information avaliable
HTM side effects and Toxicity
No information avaliable
HTM Patient Information
No information avaliable
HTM Organisms Affected
Humans and other mammals
