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HEXAMETHYLMELAMINE Brand names, HEXAMETHYLMELAMINE Analogs

HEXAMETHYLMELAMINE Brand Names Mixture

  • No information avaliable

HEXAMETHYLMELAMINE Chemical_Formula

C9H18N6

HEXAMETHYLMELAMINE RX_link

http://www.rxlist.com/cgi/generic/altretamine.htm

HEXAMETHYLMELAMINE fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=104

HEXAMETHYLMELAMINE msds (material safety sheet)

HEXAMETHYLMELAMINE Synthesis Reference

No information avaliable

HEXAMETHYLMELAMINE Molecular Weight

210.28 g/mol

HEXAMETHYLMELAMINE Melting Point

172-174 oC

HEXAMETHYLMELAMINE H2O Solubility

91 mg/L

HEXAMETHYLMELAMINE State

Solid

HEXAMETHYLMELAMINE LogP

1.566

HEXAMETHYLMELAMINE Dosage Forms

Capsule

HEXAMETHYLMELAMINE Indication

For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

HEXAMETHYLMELAMINE Pharmacology

Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.

HEXAMETHYLMELAMINE Absorption

No information avaliable

HEXAMETHYLMELAMINE side effects and Toxicity

No information avaliable

HEXAMETHYLMELAMINE Patient Information

No information avaliable

HEXAMETHYLMELAMINE Organisms Affected

Humans and other mammals