Guanethidine Sulphae
Guanethidine Sulphae Brand names, Guanethidine Sulphae Analogs
Guanethidine Sulphae Brand Names Mixture
- No information avaliable
Guanethidine Sulphae Chemical_Formula
C10H22N4
Guanethidine Sulphae RX_link
No information avaliable
Guanethidine Sulphae fda sheet
Guanethidine Sulphae msds (material safety sheet)
Guanethidine Sulphae Synthesis Reference
No information avaliable
Guanethidine Sulphae Molecular Weight
198.309 g/mol
Guanethidine Sulphae Melting Point
250 oC (sulfate salt)
Guanethidine Sulphae H2O Solubility
Very soluble
Guanethidine Sulphae State
Solid
Guanethidine Sulphae LogP
0.693
Guanethidine Sulphae Dosage Forms
Tablet
Guanethidine Sulphae Indication
For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
Guanethidine Sulphae Pharmacology
High blood pressure can cause the heart and arteries to not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.
Guanethidine Sulphae Absorption
3-30% of oral dose (poor and highly variable)
Guanethidine Sulphae side effects and Toxicity
Side effects include drowsiness, dizziness, tiredness or confusion. LD50=1000 mg/kg (mouse, oral)
Guanethidine Sulphae Patient Information
http://www.drugs.com/cons/Guanadrel.html
Guanethidine Sulphae Organisms Affected
Humans and other mammals
