Gemcitabine

Category

Gemcitabine




Useful info

Gemcitabine Brand names, Gemcitabine Analogs

Gemcitabine Brand Names Mixture

  • No information avaliable

    • Gemcitabine Chemical_Formula

    C9H11F2N3O4

    Gemcitabine RX_link

    http://www.rxlist.com/cgi/generic/gemcitab.htm

    Gemcitabine fda sheet

    Gemcitabine FDA

    Gemcitabine msds (material safety sheet)

    Gemcitabine MSDS

    Gemcitabine Synthesis Reference

    No information avaliable

    Gemcitabine Molecular Weight

    263.198 g/mol

    Gemcitabine Melting Point

    168.64oC

    Gemcitabine H2O Solubility

    Soluble

    Gemcitabine State

    Solid

    Gemcitabine LogP

    -1.318

    Gemcitabine Dosage Forms

    Lyophilized powder for injection

    Gemcitabine Indication

    For the first-line treatment of patients with metastatic breast cancer, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer and as first-line treatment for patients with adenocarcinoma of the pancreas.

    Gemcitabine Pharmacology

    Gemcitabine is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (or DNA synthesis phase of the cell cycle), stopping normal development and division. Gemcitabine blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Gemcitabine blocks the incorporation of the thymidine nucleotide into the DNA strand.

    Gemcitabine Absorption

    100%

    Gemcitabine Toxicity

    Myelosuppression, paresthesias, and severe rash were the principal toxicities, LD50=500 mg/kg (orally in mice and rats)

    Gemcitabine Patient Information

    General ¡ª Patients receiving therapy with Gemzar should be monitored closely by a physician
    experienced in the use of cancer chemotherapeutic agents. Most adverse events are reversible and
    do not need to result in discontinuation, although doses may need to be withheld or reduced.
    There was a greater tendency in women, especially older women, not to proceed to the next
    cycle.

    Laboratory Tests ¡ª Patients receiving Gemzar should be monitored prior to each dose with a
    complete blood count (CBC), including differential and platelet count. Suspension or
    modification of therapy should be considered when marrow suppression is detected.

    Gemcitabine Organisms Affected

    Humans and other mammals