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Gecophen Brand names, Gecophen Analogs

Gecophen Brand Names Mixture

  • No information avaliable

Gecophen Chemical_Formula

C52H98N16O13

Gecophen RX_link

No information avaliable

Gecophen fda sheet

Gecophen msds (material safety sheet)

Gecophen MSDS

Gecophen Synthesis Reference

No information avaliable

Gecophen Molecular Weight

2797.3193 g/mol

Gecophen Melting Point

200 - 220 oC

Gecophen H2O Solubility

5.64E+005 mg/L

Gecophen State

Solid

Gecophen LogP

-4.648

Gecophen Dosage Forms

Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)

Gecophen Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

Gecophen Pharmacology

Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

Gecophen Absorption

Very poor absorption from gastrointestinal tract.

Gecophen side effects and Toxicity

Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

Gecophen Patient Information

No information avaliable

Gecophen Organisms Affected

Gram-negative bacilli