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Gastrografin Brand names, Gastrografin Analogs

Gastrografin Brand Names Mixture

  • No information avaliable

Gastrografin Chemical_Formula

C9H15N5O3

Gastrografin RX_link

No information avaliable

Gastrografin fda sheet

Gastrografin msds (material safety sheet)

Gastrografin Synthesis Reference

No information avaliable

Gastrografin Molecular Weight

241.247 g/mol

Gastrografin Melting Point

250-255 oC (hydrochloride salt)

Gastrografin H2O Solubility

>20 mg/mL (dichloride salt)

Gastrografin State

Solid

Gastrografin LogP

-1.783

Gastrografin Dosage Forms

No information avaliable

Gastrografin Indication

For the treatment of tetrahydrobiopterin (BH4) deficiency.

Gastrografin Pharmacology

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

Gastrografin Absorption

No information avaliable

Gastrografin side effects and Toxicity

No information avaliable

Gastrografin Patient Information

No information avaliable

Gastrografin Organisms Affected

Humans and other mammals