Furazosin

• Antihypertensive Agents
• Alpha-adrenergic Blocking Agents
• ATC:C02CA01

• Furazosin
• Lentopres
• Minipress
• Minipress Xl
• Prazosin Base
• Prazosin HCl
• Prazosin Hydrochloride
• Prazosina [Inn-Spanish]
• Prazosine [Inn-French]
• Prazosinum [Inn-Latin]
• Vasoflex

• No information avaliable

C₁₉H₂₁N₅O₄

http://www.rxlist.com/cgi/generic3/prazosin.htm

Furazosin MSDS

No information avaliable

383.401 g/mol

279 ^oC

0.2 mg/mL (as HCl salt)

Solid

0.934

Tablet

For treatment of hypertension and chronic heart failure.

Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity.

Well-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).

No information avaliable

Dizziness or drowsiness may occur after the first dose of this medicine. Avoid driving or performing hazardous tasks for the first 24 hours after taking this medicine or when the dose is increased. Dizziness, light-headedness or fainting may occur, especially when rising from a lying or sitting position. Getting up slowly may help lessen the problem. These effects may also occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While taking prazosin HCl, be careful in the amount of alcohol you drink. Also, use extra care during exercise or hot weather, or if standing for long periods. Check with your physician if you have any questions.

Humans and other mammals