Fosfonomycin
Fosfonomycin Brand names, Fosfonomycin Analogs
Fosfonomycin Brand Names Mixture
- Micardis Plus (Hydrochlorothiazide + Telmisartan)
Fosfonomycin Chemical_Formula
C3H7O4P
Fosfonomycin RX_link
http://www.rxlist.com/cgi/generic2/fosfomycin.htm
Fosfonomycin fda sheet
Fosfonomycin msds (material safety sheet)
Fosfonomycin Synthesis Reference
No information avaliable
Fosfonomycin Molecular Weight
138.059 g/mol
Fosfonomycin Melting Point
94 oC
Fosfonomycin H2O Solubility
50 mg/mL (Sodium salt)
Fosfonomycin State
Solid
Fosfonomycin LogP
-0.912
Fosfonomycin Dosage Forms
Powder
Fosfonomycin Indication
For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
Fosfonomycin Pharmacology
Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.
Fosfonomycin Absorption
Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
Fosfonomycin side effects and Toxicity
LD50>5 g/kg (rats). Side effects may include diarrhea
Fosfonomycin Patient Information
No information avaliable
Fosfonomycin Organisms Affected
E. coli and other enteric bacteria
