Fludestrin
Fludestrin Brand names, Fludestrin Analogs
Fludestrin Brand Names Mixture
- No information avaliable
Fludestrin Chemical_Formula
C19H24O3
Fludestrin RX_link
http://www.rxlist.com/cgi/generic2/testolactone.htm
Fludestrin fda sheet
Fludestrin msds (material safety sheet)
Fludestrin Synthesis Reference
No information avaliable
Fludestrin Molecular Weight
300.392 g/mol
Fludestrin Melting Point
218.5 oC
Fludestrin H2O Solubility
Slightly soluble (27.4 mg/L)
Fludestrin State
Solid
Fludestrin LogP
3.663
Fludestrin Dosage Forms
For oral administration as tablets providing 50 mg testolactone per tablet
Fludestrin Indication
For palliative treatment of advanced breast cancer in postmenopausal women.
Fludestrin Pharmacology
Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. Despite some similarity to testosterone, testolactone has no in vivo androgenic effect. No other hormonal effects have been reported in clinical studies in patients receiving testolactone.
Fludestrin Absorption
Testolactone is well absorbed from the gastrointestinal tract.
Fludestrin side effects and Toxicity
Oral LD50s in mouse and dog are 1630 mg/kg and 593-926 mg/kg, respectively.
Fludestrin Patient Information
Fludestrin Organisms Affected
Humans and other mammals
