Fenobarbital Brand names, Fenobarbital Analogs
Fenobarbital Brand Names Mixture
No information avaliable
Fenobarbital fda sheet
Fenobarbital msds (material safety sheet)
Fenobarbital Synthesis Reference
Hoerlein, U.S. Pat. 1,025,872 (1912)
Fenobarbital Molecular Weight
Fenobarbital Melting Point
Fenobarbital H2O Solubility
<0.01 g/100 mL
Fenobarbital Dosage Forms
For the treatment of Epilepsy
Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal).
Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach
Fenobarbital side effects and Toxicity
CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.
Fenobarbital Patient Information
Practitioners should give the following information and instructions to patients receiving barbiturates:
1. The use of phenobarbital carries with it an associated risk of psychological and/or physical dependence.
The patient should be warned against increasing the dose of the drug without consulting a physician.
2. Phenobarbital may impair mental and/or physical abilities required for the performance of potentially
hazardous tasks (e.g., driving, operating machinery, etc.).
3. Alcohol should not be consumed while taking phenobarbital. Concurrent use of phenobarbital with other
CNS depressants (e.g., alcohol, narcotics, tranquilizers, and antihistamines) may result in additional CNS
Fenobarbital Organisms Affected
Humans and other mammals