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Fenobarbital
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Fenobarbital Brand names, Fenobarbital Analogs

Fenobarbital Brand Names Mixture

  • No information avaliable

Fenobarbital Chemical_Formula

C12H12N2O3

Fenobarbital RX_link

No information avaliable

Fenobarbital fda sheet

Fenobarbital msds (material safety sheet)

Fenobarbital MSDS

Fenobarbital Synthesis Reference

Hoerlein, U.S. Pat. 1,025,872 (1912)

Fenobarbital Molecular Weight

232.235 g/mol

Fenobarbital Melting Point

174 oC

Fenobarbital H2O Solubility

<0.01 g/100 mL

Fenobarbital State

Solid

Fenobarbital LogP

1.777

Fenobarbital Dosage Forms

Tablet; Elixir

Fenobarbital Indication

For the treatment of Epilepsy

Fenobarbital Pharmacology

Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal).

Fenobarbital Absorption

Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach

Fenobarbital side effects and Toxicity

CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.

Fenobarbital Patient Information

PATIENT INFORMATION

Practitioners should give the following information and instructions to patients receiving barbiturates:

1. The use of phenobarbital carries with it an associated risk of psychological and/or physical dependence.
The patient should be warned against increasing the dose of the drug without consulting a physician.

2. Phenobarbital may impair mental and/or physical abilities required for the performance of potentially
hazardous tasks (e.g., driving, operating machinery, etc.).

3. Alcohol should not be consumed while taking phenobarbital. Concurrent use of phenobarbital with other
CNS depressants (e.g., alcohol, narcotics, tranquilizers, and antihistamines) may result in additional CNS
depressant

Fenobarbital Organisms Affected

Humans and other mammals