Famotidine

Category

Famotidine




Useful info

Famotidine Brand names, Famotidine Analogs

Famotidine Brand Names Mixture

  • No information avaliable

    • Famotidine Chemical_Formula

    C8H15N7O2S3

    Famotidine RX_link

    http://www.rxlist.com/cgi/generic/famot.htm

    Famotidine fda sheet

    Famotidine FDA

    Famotidine msds (material safety sheet)

    Famotidine MSDS

    Famotidine Synthesis Reference

    H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

    Famotidine Molecular Weight

    337.449 g/mol

    Famotidine Melting Point

    163-164 oC

    Famotidine H2O Solubility

    1.1 mg/mL

    Famotidine State

    Solid

    Famotidine LogP

    -0.726

    Famotidine Dosage Forms

    Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

    Famotidine Indication

    For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

    Famotidine Pharmacology

    Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

    Famotidine Absorption

    The bioavailability of oral doses is 40-45%.

    Famotidine Toxicity

    Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

    Famotidine Patient Information

    Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
    hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
    reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
    physician if you are pregnant or nursing. Famotidine may be taken with or without food.
    Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
    suspension should be discarded after 30 days. Notify your physician if you develop black,
    tarry stools or coffee-ground vomit.

    Famotidine Organisms Affected

    Humans and other mammals