Ethionamide
Ethionamide Brand names, Ethionamide Analogs
Ethionamide Brand Names Mixture
- No information avaliable
Ethionamide Chemical_Formula
C8H10N2S
Ethionamide RX_link
http://www.rxlist.com/cgi/generic2/ethionamide.htm
Ethionamide fda sheet
Ethionamide msds (material safety sheet)
Ethionamide Synthesis Reference
No information avaliable
Ethionamide Molecular Weight
166.244 g/mol
Ethionamide Melting Point
163 oC
Ethionamide H2O Solubility
Practically insoluble
Ethionamide State
Solid
Ethionamide LogP
0.705
Ethionamide Dosage Forms
Tablet (250 mg)
Ethionamide Indication
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Ethionamide Pharmacology
Ethinamate is bacteriostatic against M. tuberculosis. In a study examining ethionamide resistance, ethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected mice. Drug resistance developed with continued ethionamide monotherapy, but did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
Ethionamide Absorption
Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
Ethionamide side effects and Toxicity
Symptoms of overdose include convulsions, nausea, and vomiting.
Ethionamide Patient Information
No information avaliable
Ethionamide Organisms Affected
Mycobacteria
