Erythromycin

• Anti-bacterial Agents
• ATC:D10AF02
• ATC:J01FA01
• ATC:S01AA17

• Baraclude

• No information avaliable

C₃₇H₆₇NO₁₃

http://www.rxlist.com/cgi/generic/erithrom.htm

Erythromycin FDA

Erythromycin MSDS

No information avaliable

733.927 g/mol

191 ^oC

Slightly soluble (1.44 mg/L)

Solid

1.983

Capsule; Capsule (enteric-coated); Liquid; Ointment; Powder; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated)

For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae, in the treatment of infections due to Corynebacterium minutissimum, intestinal amebiasis caused by Entamoeba histolytica, acute pelvic inflammatory disease caused by Neisseria gonorrhoeae, skin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureus, primary syphilis caused by Treponema pallidum, infections caused by Chlamydia trachomatis, nongonococcal urethritis caused by Ureaplasma urealyticum, and Legionnaires' disease caused by Legionella pneumophila.

Erythromycin is produced by a strain of Streptomyces erythraeus and belongs to the macrolide group of antibiotics. After absorption, erythromycin diffuses readily into most body fluids. In the absence of meningeal inflammation, low concentrations are normally achieved in the spinal fluid, but the passage of the drug across the blood-brain barrier increases in meningitis. Erythromycin is excreted in breast milk. The drug crosses the placental barrier, but fetal plasma levels are low. Erythromycin is not removed by peritoneal dialysis or hemodialysis.

Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor.

Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.

Enteric bacteria and other eubacteria