Epoxymexrenone
Epoxymexrenone Brand names, Epoxymexrenone Analogs
Epoxymexrenone Brand Names Mixture
- No information avaliable
Epoxymexrenone Chemical_Formula
C24H30O6
Epoxymexrenone RX_link
http://www.rxlist.com/cgi/generic/inspra.htm
Epoxymexrenone fda sheet
Epoxymexrenone msds (material safety sheet)
Epoxymexrenone Synthesis Reference
No information avaliable
Epoxymexrenone Molecular Weight
414.491 g/mol
Epoxymexrenone Melting Point
No information avaliable
Epoxymexrenone H2O Solubility
Slightly soluble
Epoxymexrenone State
Solid
Epoxymexrenone LogP
2.445
Epoxymexrenone Dosage Forms
Tablet (film-coated - 25, 50 mg)
Epoxymexrenone Indication
For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.
Epoxymexrenone Pharmacology
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
Epoxymexrenone Absorption
The absolute bioavailability of eplerenone is unknown.
Epoxymexrenone side effects and Toxicity
The most likely symptoms of human overdosage would be anticipated to be hypotension or hyperkalemia. However, no cases of human overdosage with eplerenone have been reported.
Epoxymexrenone Patient Information
Epoxymexrenone Organisms Affected
Humans and other mammals
