EACS
EACS Brand names, EACS Analogs
EACS Brand Names Mixture
- No information avaliable
EACS Chemical_Formula
C6H13NO2
EACS RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
EACS fda sheet
EACS msds (material safety sheet)
EACS Synthesis Reference
No information avaliable
EACS Molecular Weight
131.173 g/mol
EACS Melting Point
205 oC
EACS H2O Solubility
5.05E+005 mg/L
EACS State
Solid
EACS LogP
0.306
EACS Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
EACS Indication
For use in the treatment of excessive postoperative bleeding.
EACS Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
EACS Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
EACS side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
EACS Patient Information
EACS Organisms Affected
Humans and other mammals
