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Dosegran Brand names, Dosegran Analogs

Dosegran Brand Names Mixture

  • Vanectyl-P Tablets (Prednisolone + Trimeprazine Tartrate)

Dosegran Chemical_Formula

C18H22N2S

Dosegran RX_link

No information avaliable

Dosegran fda sheet

Dosegran msds (material safety sheet)

Dosegran Synthesis Reference

No information avaliable

Dosegran Molecular Weight

298.447 g/mol

Dosegran Melting Point

68 oC

Dosegran H2O Solubility

0.942 mg/L

Dosegran State

Solid

Dosegran LogP

5.162

Dosegran Dosage Forms

Tablet (2.5 mg); Syrup (2.5 mg/5mL); Capsule(5 mg)

Dosegran Indication

Used to prevent and relieve allergic conditions which cause pruritus (itching) and urticaria (some allergic skin reactions).

Dosegran Pharmacology

Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics, but differing in the ring-substitution and chain characteristics. Trimeprazine is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, trimeprazine is not used clinically as an anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic (anti-nausea). Trimeprazine is used principally as an anti-emetic, to prevent motion sickness or as an anti-histamine in combination with other medications in cough and cold preparations. Tricyclic antihistamines are also structurally-related to the tricyclic antidepressants, explaining the antihistaminergic adverse effects of these two drug classes and also the poor tolerability profile of tricyclic H1-antihistamines.

Dosegran Absorption

Well absorbed in the digestive tract.

Dosegran side effects and Toxicity

Symptoms of overdose clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.

Dosegran Patient Information

Prescriber should notify the patient to report an form of confusion, sedation, or hypotension. Inform the patient to avoid driving and other hazardous activity if drowsiness occurs. Also inform the patient to avoid alcohol and other CNS depressants while on trimeprazine.

Dosegran Organisms Affected

Humans and other mammals