Doriden
Doriden Brand names, Doriden Analogs
Doriden Brand Names Mixture
- No information avaliable
Doriden Chemical_Formula
C13H16N2O2
Doriden RX_link
http://www.rxlist.com/cgi/generic3/cytadren.htm
Doriden fda sheet
Doriden msds (material safety sheet)
Doriden Synthesis Reference
Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)
Doriden Molecular Weight
232.278 g/mol
Doriden Melting Point
149-150 oC
Doriden H2O Solubility
Practically insoluble in water
Doriden State
Solid
Doriden LogP
2.029
Doriden Dosage Forms
Tablet (250 mg)
Doriden Indication
For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
Doriden Pharmacology
Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.
Doriden Absorption
Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.
Doriden side effects and Toxicity
Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.
Doriden Patient Information
Doriden Organisms Affected
Humans and other mammals
