Dopram

• Central Nervous System Stimulants
• Respiratory System Agents
• ATC:R07AB01

• Dopram
• Doxapram HCL
• Doxapram hydrochloride
• Stimulexin

• No information avaliable

C₂₄H₃₀N₂O₂

http://www.rxlist.com/cgi/generic2/doxapram.htm

Dopram FDA

Dopram MSDS

No information avaliable

378.507 g/mol

No information avaliable

Sparingly soluble

Solid

3.938

Liquid; Solution

For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.

Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.

No information avaliable

Intravenous LD₅₀ values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.

No information avaliable

Humans and other mammals