Dophamine

Dophamine Brand names, Dophamine Analogs

Dophamine Brand Names Mixture

No information avaliable

Dophamine Chemical_Formula

C₈H₁₁NO₂

Dophamine RX_link

http://www.rxlist.com/cgi/generic3/dopamine.htm

Dophamine fda sheet

Dophamine msds (material safety sheet)

Dophamine MSDS

Dophamine Synthesis Reference

No information avaliable

Dophamine Molecular Weight

153.178 g/mol

Dophamine Melting Point

82.5 ^oC

Dophamine H₂O Solubility

600 g/L

Dophamine State

Solid

Dophamine LogP

0.548

Dophamine Dosage Forms

Solution

Dophamine Indication

For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure

Dophamine Pharmacology

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.

Dophamine Absorption

Dopamine is rapidly absorbed from the small intestine.

Dophamine side effects and Toxicity

LD₅₀ oral mice = 1460 mg/kg, LD₅₀ oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

Dophamine Patient Information