Dopamine

• Cardiotonic Agents
• Sympathomimetic
• ATC:C01CA04

• DA
• Deoxyepinephrine
• Dopamin
• Dopamine HCl
• Dophamine
• Hydroxytyramin
• Hydroxytyramine
• Intropin
• Oxytyramine
• Revimine

• No information avaliable

C₈H₁₁NO₂

http://www.rxlist.com/cgi/generic3/dopamine.htm

Dopamine MSDS

No information avaliable

153.178 g/mol

82.5 ^oC

600 g/L

Solid

0.548

Solution

For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.

Dopamine is rapidly absorbed from the small intestine.

LD₅₀ oral mice = 1460 mg/kg, LD₅₀ oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

No information avaliable

Humans and other mammals