Diphenoxylate Hydrochloride en es it fr

Diphenoxylate Hydrochloride Brand names, Diphenoxylate Hydrochloride Analogs

Diphenoxylate Hydrochloride Brand Names Mixture

  • Lomotil (Atropine Sulfate + Diphenoxylate Hcl)

Diphenoxylate Hydrochloride Chemical_Formula

C30H32N2O2

Diphenoxylate Hydrochloride RX_link

http://www.rxlist.com/cgi/generic3/diphenoxylate.htm

Diphenoxylate Hydrochloride fda sheet

Diphenoxylate Hydrochloride msds (material safety sheet)

Diphenoxylate_Hydrochloride MSDS

Diphenoxylate Hydrochloride Synthesis Reference

Janssen, U.S. pat. 2,898,340 (1959)

Diphenoxylate Hydrochloride Molecular Weight

452.587 g/mol

Diphenoxylate Hydrochloride Melting Point

221 oC

Diphenoxylate Hydrochloride H2O Solubility

0.8 mg/ml

Diphenoxylate Hydrochloride State

Solid

Diphenoxylate Hydrochloride LogP

7.385

Diphenoxylate Hydrochloride Dosage Forms

Oral solution; Tablet

Diphenoxylate Hydrochloride Indication

For as adjunctive therapy in the management of diarrhea

Diphenoxylate Hydrochloride Pharmacology

Diphenoxylate, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea. Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood.

Diphenoxylate Hydrochloride Absorption

90%

Diphenoxylate Hydrochloride side effects and Toxicity

Coma, dry skin and mucous membranes, enlarged pupils of the eyes, extremely high body temperature, flushing, involuntary eyeball movement, lower than normal muscle tone, pinpoint pupils, rapid heartbeat, restlessness, sluggishness, suppressed breathing

Diphenoxylate Hydrochloride Patient Information

INFORM THE PATIENT (PARENT OR GUARDIAN) NOT TO EXCEED THE RECOMMENDED DOSAGE AND TO KEEP DIPHEN-OXYLATE HCL AND ATROPINE SULFATE OUT OF THE REACH OF CHILDREN AND IN A CHILD-RESISTANT CONTAINER, INFORM THE PATIENT OF THE CONSEQUENCES OF OVERDOSAGE, INCLUDING SEVERE RESPIRATORY DEPRESSION AND COMA, POSSIBLY LEADING TO PERMANENT BRAIN DAMAGE OR DEATH.

Diphenoxylate HCl and atropine sulfate may produce drowsiness or dizziness. The patient should be cautioned regarding activities requiring mental alertness, such as driving or operati ng dangerous machinery. Potentiation of the action of alcohol, barbiturates and tranquilizers with concomitant use of diphenoxylate HCl and atropine sulfate should be explained to the patient. The physician should also provide the patient with other information in this labeling, as appropriate.

Diphenoxylate Hydrochloride Organisms Affected

Humans and other mammals