Danoflox en es it fr

Danoflox Brand names, Danoflox Analogs

Danoflox Brand Names Mixture

  • No information avaliable

Danoflox Chemical_Formula

C18H20FN3O4

Danoflox RX_link

http://www.rxlist.com/cgi/generic/oflox.htm

Danoflox fda sheet

Danoflox FDA

Danoflox msds (material safety sheet)

Danoflox MSDS

Danoflox Synthesis Reference

I. Hayakava et al., U.S. Pat. 4,382,892 (1983)

Danoflox Molecular Weight

361.368 g/mol

Danoflox Melting Point

250-257 oC

Danoflox H2O Solubility

28.3 mg/mL

Danoflox State

Solid

Danoflox LogP

1.268

Danoflox Dosage Forms

Solution (IV injection); Tablet; Opthalmic drops

Danoflox Indication

For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.

Danoflox Pharmacology

Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

Danoflox Absorption

Bioavailability of ofloxacin in the tablet formulation is approximately 98%

Danoflox side effects and Toxicity

LD50=5450 mg/kg (orally in mice)

Danoflox Patient Information

PATIENT INFORMATION
Patients should be advised:

- to drink fluids liberally;

- that mineral supplements, vitamins with iron or minerals, calcium- , aluminum-, or magnesium-based
antacids, sucralfate or Videx®, (Didanosine), chewable/buffered tablets or the pediatric powder for
oral solution should not be taken within the two-hour period before or within the two-hour period after
taking ofloxacin (See Drug Interactions);

- that ofloxacin can be taken without regard to meals;

- that ofloxacin may cause neurologic adverse effects (e. g. , dizziness, lightheadedness) and that
patients should know how they react to ofloxacin before they operate an automobile or machinery or
engage in activities requiring mental alertness and coordination

- to discontinue treatment and inform their physician if they experience pain, inflammation, or rupture
of a tendon, and to rest and refrain from exercise until the diagnosis of tendinitis or tendon rupture
has been confidently excluded;



- that ofloxacin may be associated with hypersensitivity reactions, even following the first dose, to
discontinue the drug at the first sign of a skin rash, hives or other skin reactions, a rapid heartbeat,
difficulty in swallowing or breathing, any swelling suggesting angioedema (e. g. , swelling of the lips,
tongue, face; tightness of the throat, hoarseness), or any other symptom of an allergic reaction

- to avoid excessive sunlight or artificial ultraviolet light while receiving ofloxacin and to discontinue
therapy if phototoxicity (e. g. , skin eruption) occurs;

- that if they are diabetic and are being treated with insulin or an oral hypoglycemic drug, to discontinue
ofloxacin immediately if a hypoglycemic reaction occurs and consult a physician

- that convulsions have been reported in patients taking quinolones, including ofloxacin, and to notify their
physician before taking this drug if there is a history of this condition.

Danoflox Organisms Affected

Enteric bacteria and other eubacteria