Damide

Damide Brand names, Damide Analogs

Damide Brand Names Mixture

No information avaliable

Damide Chemical_Formula

C₁₆H₁₆ClN₃O₃S

Damide RX_link

http://www.rxlist.com/cgi/generic/indap.htm

Damide fda sheet

Damide FDA

Damide msds (material safety sheet)

Damide MSDS

Damide Synthesis Reference

No information avaliable

Damide Molecular Weight

365.835 g/mol

Damide Melting Point

161 ^oC

Damide H₂O Solubility

75 mg/L

Damide State

Solid

Damide LogP

2.088

Damide Dosage Forms

Tablet

Damide Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.

Damide Pharmacology

Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Damide Absorption

Rapidly absorbed from gastrointestinal tract.

Damide side effects and Toxicity

Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness

Damide Patient Information