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DFDC Brand names, DFDC Analogs

DFDC Brand Names Mixture

  • No information avaliable

DFDC Chemical_Formula


DFDC RX_link


DFDC fda sheet


DFDC msds (material safety sheet)


DFDC Synthesis Reference

No information avaliable

DFDC Molecular Weight

263.198 g/mol

DFDC Melting Point


DFDC H2O Solubility


DFDC State




DFDC Dosage Forms

Lyophilized powder for injection

DFDC Indication

For the first-line treatment of patients with metastatic breast cancer, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer and as first-line treatment for patients with adenocarcinoma of the pancreas.

DFDC Pharmacology

Gemcitabine is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (or DNA synthesis phase of the cell cycle), stopping normal development and division. Gemcitabine blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Gemcitabine blocks the incorporation of the thymidine nucleotide into the DNA strand.

DFDC Absorption


DFDC side effects and Toxicity

Myelosuppression, paresthesias, and severe rash were the principal toxicities, LD50=500 mg/kg (orally in mice and rats)

DFDC Patient Information

General Patients receiving therapy with Gemzar should be monitored closely by a physician
experienced in the use of cancer chemotherapeutic agents. Most adverse events are reversible and
do not need to result in discontinuation, although doses may need to be withheld or reduced.
There was a greater tendency in women, especially older women, not to proceed to the next

Laboratory Tests Patients receiving Gemzar should be monitored prior to each dose with a
complete blood count (CBC), including differential and platelet count. Suspension or
modification of therapy should be considered when marrow suppression is detected.

DFDC Organisms Affected

Humans and other mammals