Cyklofosfamid en es it fr

Cyklofosfamid Brand names, Cyklofosfamid Analogs

Cyklofosfamid Brand Names Mixture

  • Procytox for Injection 2000mg Pws Iv (Cyclophosphamide + Sodium Chloride)

Cyklofosfamid Chemical_Formula


Cyklofosfamid RX_link

Cyklofosfamid fda sheet

Cyklofosfamid msds (material safety sheet)

Cyklofosfamid MSDS

Cyklofosfamid Synthesis Reference

Arnold et al, Angew.Chem., 70; 539; 543(1958)

Cyklofosfamid Molecular Weight

261.085 g/mol

Cyklofosfamid Melting Point

41-45 oC

Cyklofosfamid H2O Solubility

Soluble. 1-5 g/100 mL at 23 oC

Cyklofosfamid State


Cyklofosfamid LogP

No information avaliable

Cyklofosfamid Dosage Forms

Oral tablets; Oral liquid; Parenteral solution

Cyklofosfamid Indication

For management of malignant lymphomas, multiple myeloma,leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma and carcinoma of the breast

Cyklofosfamid Pharmacology

Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Cyklofosfamid Absorption


Cyklofosfamid side effects and Toxicity

infection, myelosuppression, and cardiac toxicity

Cyklofosfamid Patient Information

This medicine is a type of chemotherapy for treating cancers of the blood
and certain other cancers. This medicine interferes with the way cancer
cells grow. Take your doses on a regular scheduled time and DO NOT take
this medicine more often than directed by your health care provider.
Finish the full course prescribed by your health care provider. DO NOT
stop taking this medicine unless diredted to do so by your health care
provider. While taking this medicine, you make get infection more easily.
Call your doctor if you get a fever, chills, or sore throat. Drink plenty
of water with this medicine.

Cyklofosfamid Organisms Affected

Humans and other mammals