Compactin
Compactin Brand names, Compactin Analogs
Compactin Brand Names Mixture
- No information avaliable
Compactin Chemical_Formula
C23H36O7
Compactin RX_link
http://www.rxlist.com/cgi/generic/pravast.htm
Compactin fda sheet
Compactin msds (material safety sheet)
Compactin Synthesis Reference
A. Terahara, M.Tanaka, U.S. Pat. 4,346,227(1982)
Compactin Molecular Weight
424.528 g/mol
Compactin Melting Point
326oC
Compactin H2O Solubility
2464mg/L
Compactin State
Solid
Compactin LogP
2.613
Compactin Dosage Forms
Tablet
Compactin Indication
For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.
Compactin Pharmacology
Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation.
Compactin Absorption
Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.
Compactin side effects and Toxicity
Rhabdomyolysis; LD50=mg/kg (orally in rat)
Compactin Patient Information
Patients should be advised to report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.
Compactin Organisms Affected
Humans and other mammals
