Colistin methanesulfonate sodium salt
Colistin methanesulfonate sodium salt Brand names, Colistin methanesulfonate sodium salt Analogs
Colistin methanesulfonate sodium salt Brand Names Mixture
- No information avaliable
Colistin methanesulfonate sodium salt Chemical_Formula
C32H52Br2N4O4
Colistin methanesulfonate sodium salt RX_link
http://www.rxlist.com/cgi/generic2/demecarium.htm
Colistin methanesulfonate sodium salt fda sheet
Colistin methanesulfonate sodium salt msds (material safety sheet)
Colistin methanesulfonate sodium salt Synthesis Reference
No information avaliable
Colistin methanesulfonate sodium salt Molecular Weight
716.588 g/mol
Colistin methanesulfonate sodium salt Melting Point
No information avaliable
Colistin methanesulfonate sodium salt H2O Solubility
No information avaliable
Colistin methanesulfonate sodium salt State
Solid
Colistin methanesulfonate sodium salt LogP
-1.75
Colistin methanesulfonate sodium salt Dosage Forms
Solution (drops - 0.125% and 0.25%)
Colistin methanesulfonate sodium salt Indication
For the topical treatment of chronic open-angle glaucoma.
Colistin methanesulfonate sodium salt Pharmacology
Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.
Colistin methanesulfonate sodium salt Absorption
No information avaliable
Colistin methanesulfonate sodium salt side effects and Toxicity
The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.
Colistin methanesulfonate sodium salt Patient Information
No information avaliable
Colistin methanesulfonate sodium salt Organisms Affected
Humans and other mammals
