Colistimethate sodium en es it fr

Colistimethate sodium Brand names, Colistimethate sodium Analogs

Colistimethate sodium Brand Names Mixture

  • No information avaliable

Colistimethate sodium Chemical_Formula

C32H52Br2N4O4

Colistimethate sodium RX_link

http://www.rxlist.com/cgi/generic2/demecarium.htm

Colistimethate sodium fda sheet

Colistimethate sodium msds (material safety sheet)

Colistimethate sodium Synthesis Reference

No information avaliable

Colistimethate sodium Molecular Weight

716.588 g/mol

Colistimethate sodium Melting Point

No information avaliable

Colistimethate sodium H2O Solubility

No information avaliable

Colistimethate sodium State

Solid

Colistimethate sodium LogP

-1.75

Colistimethate sodium Dosage Forms

Solution (drops - 0.125% and 0.25%)

Colistimethate sodium Indication

For the topical treatment of chronic open-angle glaucoma.

Colistimethate sodium Pharmacology

Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.

Colistimethate sodium Absorption

No information avaliable

Colistimethate sodium side effects and Toxicity

The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.

Colistimethate sodium Patient Information

No information avaliable

Colistimethate sodium Organisms Affected

Humans and other mammals