Colistimethale Sodium

• Cholinergic Agents
• Miotics
• ATC:S01EB04

• Colistimethale Sodium
• Colistimethate sodium
• Colistin methanesulfonate sodium salt
• Colistin sodium methanesulfonate
• Colistin sodium methanesulfonate from bacillus colistinus
• Coly-mycin M

• No information avaliable

C₃₂H₅₂Br₂N₄O₄

http://www.rxlist.com/cgi/generic2/demecarium.htm

No information avaliable

716.588 g/mol

No information avaliable

No information avaliable

Solid

-1.75

Solution (drops - 0.125% and 0.25%)

For the topical treatment of chronic open-angle glaucoma.

Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.

No information avaliable

The oral LD₅₀ is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.

No information avaliable

Humans and other mammals